PD-1: Simple Plex
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells.
When PD-1-expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. The recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
Products:
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PD-1: Simple Plex
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells.
When PD-1-expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. The recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
Products:
Simple Plex Human PD-1 assay kit for use on Ella instrument. Contains cartridge, Sample Diluent SD13, and Wash Buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.