PDGF R beta: Proteins and Enzymes
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Products:
8 results for "PDGF R beta Proteins and Enzymes" in Products
8 results for "PDGF R beta Proteins and Enzymes" in Products
PDGF R beta: Proteins and Enzymes
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Products:
| Source: | NS0 |
| Accession #: | P09619 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | AAA36427.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P05622 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q05030.2 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P05622 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | AAA36427.1 |
| Applications: | BA |
Biotinylated
| Source: | CHO |
| Accession #: | AAA36427.1 |
| Applications: | BA, BA |
| Applications: | AC |