PRAME: Proteins and Enzymes
PRAME encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Recent data from Epping et.al., (Cell, Vol. 122: 835) suggest that overexpression of PRAME frequently observed in human cancers confers growth or survival advantages by antagonizing RAR signaling.
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3 results for "PRAME Proteins and Enzymes" in Products
3 results for "PRAME Proteins and Enzymes" in Products
PRAME: Proteins and Enzymes
PRAME encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Recent data from Epping et.al., (Cell, Vol. 122: 835) suggest that overexpression of PRAME frequently observed in human cancers confers growth or survival advantages by antagonizing RAR signaling.
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| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human PRAME GST (N-Term) Protein [H00023532-P01]](https://resources.bio-techne.com/images/products/Recombinant-Human-PRAME-Protein-SDS-Page-H00023532-P01-img0002.jpg "SDS-PAGE: Recombinant Human PRAME GST (N-Term) Protein [H00023532-P01]")
| Applications: | AC |
| Applications: | AC |