PTP gamma/PTPRG: Proteins and Enzymes

Protein Tyrosine Phosphatase, Receptor type gamma (PTPR gamma), also called PTPRG and PTPG, is a transmembrane protein. Its extracellular region contains carbonic anhydrase fibronectin III domains, suggesting that it interacts with adhesion molecules, but the only reported activator is an intracellular ATP-dependent factor. During brain development, PTPR gamma is found exclusively in post-mitotic neurons. A wide variety of cancers, including colon, renal clear cell, lung, breast, and cervical cancers, show a high incidence of defects in the PTPR gamma gene, suggesting the protein has a key regulatory function in tumor suppression.