PTPLB: Proteins and Enzymes

PTPLB, also known as Protein-Tyrosine Phosphatase-Like Member B, is a short, 254 amino acid long protein that is approximately 28kDa. PTPLB localizes to the membrane of the Endoplasmic Reticulum and is ubiquitously expressed in a variety of tissues including heart, spleen, prostate, colon, and testes. PTPLB is involved in VLCFA synthesis and interacts with BCAP31 and members of the ELOVL family of enzymes. Current research on PTPLB is being performed in relation to several diseases and disorders including malaria and prostatitis.