Secretagogin: Proteins and Enzymes

Secretagogin (SCGN) is a 32 kDa member of the EF-hand family of Ca²⁺-binding proteins. Secretagogin is expressed in select neurons, as well as neuroendocrine cells and pancreatic islets. Human Secretagogin is 276 amino acids (aa) in length and contains six 35 aa EF-hand domains (aa 12 - 276). There is one alternative splice variant of Secretagogin that shows a 22 aa substitution for aa 28 - 276, and which demonstrates no Ca²⁺-binding ability. Secretagogin is known to circulate, presumably released during cell apoptosis. Over aa 164 - 276, human Secretagogin is more than 97% aa identical to mouse, porcine and canine Secretagogin.