Siglec-8: Proteins and Enzymes
Siglec-8, also known as SAF, is a transmembrane lectin that is expressed on eosinophils, basophils, and mast cells and shows a binding preference for the carbohydrate 6-O sulfated sLe(x). The functional paralog of human Siglec-8 is known as Siglec-F in mouse. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha-induced mast cell degranulation. It also induces eosinophil apoptosis, an effect that is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
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2 results for "Siglec-8 Proteins and Enzymes" in Products
2 results for "Siglec-8 Proteins and Enzymes" in Products
Siglec-8: Proteins and Enzymes
Siglec-8, also known as SAF, is a transmembrane lectin that is expressed on eosinophils, basophils, and mast cells and shows a binding preference for the carbohydrate 6-O sulfated sLe(x). The functional paralog of human Siglec-8 is known as Siglec-F in mouse. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha-induced mast cell degranulation. It also induces eosinophil apoptosis, an effect that is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Products:
| Source: | NS0 |
| Accession #: | AAH53319 |
| Applications: | BA |
| Applications: | AC |