SMPD1 Products
Sphingomyelin phosphodiesterase, also known as acid sphingomyelinase and encoded by the SMPD1 gene, is a lysosomal phosphodiesterase which belongs to the acid sphingomyelinase family. SMPD1 catalyzes the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Ceramide, a bioactive lipid, has emerged as an important signaling molecule involved in a variety of cellular processes such as cell differentiation, apoptosis, and proliferation. Activation of SMPD1 occurs by the removal, chemical modification or dimerization of its C-terminal cysteine residue. Deficiencies of SMPD1 result in a lysosomal storage disorder referred to as Niemann-Pick disease. rhSMPD1 was expressed without the last three C-terminal residues, and is therefore constitutively active.
73 results for "SMPD1" in Products
73 results for "SMPD1" in Products
SMPD1 Products
Sphingomyelin phosphodiesterase, also known as acid sphingomyelinase and encoded by the SMPD1 gene, is a lysosomal phosphodiesterase which belongs to the acid sphingomyelinase family. SMPD1 catalyzes the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Ceramide, a bioactive lipid, has emerged as an important signaling molecule involved in a variety of cellular processes such as cell differentiation, apoptosis, and proliferation. Activation of SMPD1 occurs by the removal, chemical modification or dimerization of its C-terminal cysteine residue. Deficiencies of SMPD1 result in a lysosomal storage disorder referred to as Niemann-Pick disease. rhSMPD1 was expressed without the last three C-terminal residues, and is therefore constitutively active.
Reactivity: | Human, Mouse |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB, ICC/IF, Flow |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, Simple Western |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #563418 |
Applications: | IP, Neut |
Source: | CHO |
Accession #: | NP_000534 |
Applications: | EnzAct |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ELISA, Flow |
Source: | CHO |
Accession #: | Q04519 |
Applications: | EnzAct |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | WB |
Applications: | ELISA |
Reactivity: | Human |
Details: | Rabbit Polyclonal |
Applications: | WB, ELISA |
Reactivity: | Human |
Details: | Mouse IgG2a Kappa Monoclonal Clone #4H2 |
Applications: | WB, ELISA |
Applications: | ELISA |
Applications: | WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #OTI3H7 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #09 |
Applications: | ELISA |
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
Chemical Name: | 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one |
Purity: | ≥98% (HPLC) |