Snail: Proteins and Enzymes

Snail (Snail-1) is a C2H2-type zinc-finger transcription factor that is associated with neural crest formation in chick, and left-right asymmetry development in mice. Snail is particularly known to repress E-Cadherin expression, regulating epithelial-to-mesenchymal transitions and cell migration. Snail family members influence cell behaviour during development and diseases such as metastatic cancer, where they act primarily as survival factors and inducers of cell movement.