Sonic Hedgehog/Shh: Proteins and Enzymes
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
12 results for "Sonic Hedgehog/Shh Proteins and Enzymes" in Products
12 results for "Sonic Hedgehog/Shh Proteins and Enzymes" in Products
Sonic Hedgehog/Shh: Proteins and Enzymes
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
C-terminal cholesterol, N-terminal fatty acid-modified
| Source: | HEK293 |
| Accession #: | Q15465 |
| Applications: | BA |
Intended for preclinical researchers who may transition to GMP Sonic Hedgehog/Shh (C24II) for their clinical work
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | Q15465 |
| Applications: | BA |
Animal-Free
| Source: | E. coli |
| Accession #: | Q15465.1 |
| Applications: | BA |
Animal-Free
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Applications: | AC |
| Applications: | PAGE, Bioactivity |
![SDS-PAGE: Recombinant Human Sonic Hedgehog/Shh Protein [NBP2-35265]](https://resources.bio-techne.com/images/products/Human-Sonic-Hedgehog-Shh-Protein-SDS-Page-NBP2-35265-img0001.jpg "SDS-PAGE: Recombinant Human Sonic Hedgehog/Shh Protein [NBP2-35265]")
| Applications: | PAGE, Bioactivity |
| Applications: | PAGE, Bioactivity |
![SDS-PAGE: Recombinant Mouse Sonic Hedgehog/Shh Protein [NBP2-35174]](https://resources.bio-techne.com/images/products/Mouse-Sonic-Hedgehog-Shh-Protein-SDS-Page-NBP2-35174-img0001.jpg "SDS-PAGE: Recombinant Mouse Sonic Hedgehog/Shh Protein [NBP2-35174]")