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Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor-binding domain.

The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

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117 results for "Spike RBD Proteins and Enzymes" in Products

117 results for "Spike RBD Proteins and Enzymes" in Products

Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor-binding domain.

The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

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Applications: BA

HEK293 Expressed, High ACE-2 Binding

Applications: BA

His-tag

Mammalian CHO Cell Expressed, High ACE-2 Binding

Delta Variant (India) L452R T478K

Tn5 Insect Cell Expressed, High ACE-2 Binding Analyzed by SEC-MALS

Biotinylated via Amines

HEK293 Expressed

Applications: BA, BA

Biotinylated

Applications: BA

Omicron Variant

Delta Variant (India)

Applications: BA

Kappa Variant L452R E484Q

Applications: BA

N501Y Mutation found in Alpha, Beta, and Gamma Variants

Beta Variant (South Africa), K417N, E484K, N501Y

HEK293 Expressed, High ACE-2 Binding

Applications: BA

Omicron Variant Biotinylated His-tag Avi-tag

Applications: BA

Sf21 Expressed, High ACE-2 Binding

Applications: BA

Lambda Variant L452Q, F490S

Applications: BA

A.23.1 Variant

Applications: BA

Gly476Ser Point Mutation

Applications: BA
Applications: BA
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