Thrombopoietin/Tpo Products
Thrombopoietin (Tpo), is a key regulator of megakaryocytopoiesis and thrombopoiesis. It is principally produced in the liver and is bound and internalized by the receptor Tpo R/c-mpl. Defects in the Tpo-Tpo R signaling pathway are associated with a variety of platelet disorders. Tpo promotes the differentiation, proliferation, and maturation of megakaryocytes and their progenitors. Tpo additionally promotes platelet production, aggregation, ECM adhesion, and activation. Aside from its hematopoietic effects, Tpo is expressed in the brain where it promotes the apoptosis of hypoxia-sensitized neurons and inhibits neuronal differentiation by blocking NGF-induced signaling.
55 results for "Thrombopoietin/Tpo" in Products
55 results for "Thrombopoietin/Tpo" in Products
Thrombopoietin/Tpo Products
Thrombopoietin (Tpo), is a key regulator of megakaryocytopoiesis and thrombopoiesis. It is principally produced in the liver and is bound and internalized by the receptor Tpo R/c-mpl. Defects in the Tpo-Tpo R signaling pathway are associated with a variety of platelet disorders. Tpo promotes the differentiation, proliferation, and maturation of megakaryocytes and their progenitors. Tpo additionally promotes platelet production, aggregation, ECM adhesion, and activation. Aside from its hematopoietic effects, Tpo is expressed in the brain where it promotes the apoptosis of hypoxia-sensitized neurons and inhibits neuronal differentiation by blocking NGF-induced signaling.
| Source: | E. coli |
| Accession #: | NP_000451.1 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | NP_000451.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #34817 |
| Applications: | Neut |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #378120 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #34840 |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #34863 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1065103 |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | P40225 |
| Applications: | BA |
Animal Free
| Source: | E. coli |
| Accession #: | NP_000451.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P40226 |
| Applications: | BA |
| Sensitivity: | 20 pg/mL |
| Applications: | ELISA |
| Assay Range: | 62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Citrate Plasma) |
| Source: | E. coli |
| Accession #: | NP_000451 |
| Applications: | BA |
For use with catalog number DTP00B
| Applications: | ELISA, Ctrl |
| Source: | Sf 21 (baculovirus) |
| Accession #: | P40225 |
| Applications: | BA |
Analyzed by SEC-MALS. His-tag (HEK-293-expressed)
| Source: | HEK293 |
| Accession #: | P40225.1 |
| Applications: | BA |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1B11 |
| Applications: | WB, ELISA, Flow, CyTOF-ready |
![Western Blot: Thrombopoietin/THPO Antibody (1B11)BSA Free [NBP2-37498]](https://resources.bio-techne.com/images/products/Thrombopoietin-Tpo-Antibody-1B11-Western-Blot-NBP2-37498-img0002.jpg "Western Blot: Thrombopoietin/THPO Antibody (1B11)BSA Free [NBP2-37498]")
| Assay Range: | 93.8 - 6,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Rat |
| Details: | Mouse IgG1 kappa Monoclonal Clone #C2 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0566-1Z3 |
| Applications: | WB |
![Western Blot: Thrombopoietin/THPO Antibody (MM0566-1Z3)Azide and BSA Free [NBP2-11922]](https://resources.bio-techne.com/images/products/Thrombopoietin-THPO-Antibody-MM0566-1Z3-Western-Blot-NBP2-11922-img0001.jpg "Western Blot: Thrombopoietin/THPO Antibody (MM0566-1Z3)Azide and BSA Free [NBP2-11922]")
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2T1W5 |
| Applications: | WB, ELISA |
Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
| Applications: | WB |
![Western Blot: Thrombopoietin/THPO Overexpression Lysate [NBP2-10672]](https://resources.bio-techne.com/images/products/Thrombopoietin-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-10672-img0001.jpg "Western Blot: Thrombopoietin/THPO Overexpression Lysate [NBP2-10672]")