TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
253 results for "TIM-3" in Products
253 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
For use with catalog number DTIM30
| Applications: | Ctrl |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #108 |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #024 |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
Recombinant Monoclonal Antibody
| Reactivity: | Mouse |
| Details: | Rabbit IgG Kappa Monoclonal Clone #2C12 |
| Applications: | IHC, ICC/IF, Flow, B/N |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #024 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #024 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #sabatolimab |
| Applications: | ELISA, Flow, Func |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #sabatolimab |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #cobolimab |
| Applications: | ELISA, Flow, Func |