TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
6 results for "TIM-3" in Products
6 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, +1 More |
| Source: | NS0 |
| Accession #: | Q8TDQ0 |
| Applications: | Bind |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
| Source: | HEK293 |
| Accession #: | EHH54703 |
| Applications: | BA, Bind |
