TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
115 results for "TIM-3" in Products
115 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-reported |
Clone F38-2E2 was used by HLDA to establish CD designation.
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #F38-2E2 |
| Applications: | Flow |
![Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-F38-2E2-Flow-Cytometry-NBP2-27220-img0002.jpg "Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]")
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #344801 |
| Applications: | AgAct |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215015 |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #215008 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
![Western Blot: TIM-3 Antibody (OTI2E2) [NBP2-45933]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-2E2-Western-Blot-NBP2-45933-img0009.jpg "Western Blot: TIM-3 Antibody (OTI2E2) [NBP2-45933]")
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
Clone 344823 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |