TREM2: Simple Plex
TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a transmembrane protein that is expressed on newly differentiated and alternatively activated tissue macrophages, immature myeloid dendritic cells, and osteoclasts. TREM2 interacts with and modifies signaling through dendritic cells and osteoclast Plexin A1, a semaphorin receptor. It is active in several settings that involve membrane fusion, including phagocytosis of microbes by macrophages and apoptotic neurons by microglia, and the formation of osteoclasts and multinucleated giant cells from macrophages.
TREM2 signals through the adaptor protein DAP12 and can associate with the linker protein LAT2 to inhibit macrophage activation. A soluble isoform of TREM2 antagonizes full-length TREM2 and is elevated in cerebrospinal fluid of patients with active multiple sclerosis.
Products:
5 results for "TREM2 Simple Plex" in Products
5 results for "TREM2 Simple Plex" in Products
TREM2: Simple Plex
TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a transmembrane protein that is expressed on newly differentiated and alternatively activated tissue macrophages, immature myeloid dendritic cells, and osteoclasts. TREM2 interacts with and modifies signaling through dendritic cells and osteoclast Plexin A1, a semaphorin receptor. It is active in several settings that involve membrane fusion, including phagocytosis of microbes by macrophages and apoptotic neurons by microglia, and the formation of osteoclasts and multinucleated giant cells from macrophages.
TREM2 signals through the adaptor protein DAP12 and can associate with the linker protein LAT2 to inhibit macrophage activation. A soluble isoform of TREM2 antagonizes full-length TREM2 and is elevated in cerebrospinal fluid of patients with active multiple sclerosis.
Products:
Control for use with Human TREM2 Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
Simple Plex Human TREM-2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
Simple Plex Mouse/Rat TREM-2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD09, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Control for use with Mouse/Rat TREM-2 Simple Plex Assay Cartridge Kit
| Applications: | Simple Plex |