XCR1: cDNA Clones

XCR1 is a 38 kDa member of the G-protein coupled receptor 1 family. It binds the C chemokines: XCL1/lymphotactin/SCM-1alpha and XCL2/SCM-1beta. In addition, human herpesvirus 8 (HHV8) encodes two viral chemokines vCCL2/vMIP-II and vCCL3/vMIP-III that function as an antagonist and a highly selective agonist, respectively, for XCR1. XCR1 is expressed on neutrophils, CD8+ T cells, NK cells, CD4+ T cells and B cells.