cIAP-2/HIAP-1 Products
cIAP-2 (also known as MIHC and HIAP-1) is a member of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. cIAP-2 has 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). cIAP-2 inhibits caspases through the direct interaction of its BIR domain with the active caspase. Caspase activity may be restored through interactions with the Reaper like motif on mitochondrial proteins such as SMAC/Diablo or HtrA2/Omi. cIAP-2 is reported to be cleaved by HtrA2/Omi.
84 results for "cIAP-2/HIAP-1" in Products
84 results for "cIAP-2/HIAP-1" in Products
cIAP-2/HIAP-1 Products
cIAP-2 (also known as MIHC and HIAP-1) is a member of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. cIAP-2 has 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). cIAP-2 inhibits caspases through the direct interaction of its BIR domain with the active caspase. Caspase activity may be restored through interactions with the Reaper like motif on mitochondrial proteins such as SMAC/Diablo or HtrA2/Omi. cIAP-2 is reported to be cleaved by HtrA2/Omi.
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Monoclonal Clone #315301 |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, IHC |
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #315304 |
| Applications: | WB, Simple Western, IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
![Western Blot: cIAP-2/HIAP-1 AntibodyBSA Free [NBP1-27972]](https://resources.bio-techne.com/images/products/cIAP-2-HIAP-1-Antibody-Western-Blot-NBP1-27972-img0009.jpg "Western Blot: cIAP-2/HIAP-1 AntibodyBSA Free [NBP1-27972]")
| Source: | Sf 21 (baculovirus) |
| Accession #: | O95407 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: cIAP-2/HIAP-1 Antibody [NBP1-90132]](https://resources.bio-techne.com/images/products/cIAP-2-HIAP-1-Antibody-Western-Blot-NBP1-90132-img0017.jpg "Western Blot: cIAP-2/HIAP-1 Antibody [NBP1-90132]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | E. coli |
| Accession #: | Q13489 |
| Applications: | InhibAct |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Immunohistochemistry: cIAP-2/HIAP-1 Antibody [NB100-56132]](https://resources.bio-techne.com/images/products/cIAP-2-HIAP-1-Antibody-Immunohistochemistry-NB100-56132-img0005.jpg "Immunohistochemistry: cIAP-2/HIAP-1 Antibody [NB100-56132]")
Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Dimeric Smac mimetic; potent IAP inhibitor
| Chemical Name: | 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| Purity: | ≥97% (HPLC) |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #SR2173 |
| Applications: | IHC, WB, ICC/IF, IP |
| Applications: | AC |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1A9 |
| Applications: | WB, Flow |
![Western Blot: cIAP-2/HIAP-1 Antibody (OTI1A9) [NBP2-46576]](https://resources.bio-techne.com/images/products/cIAP-2-HIAP-1-Antibody-OTI1A9-Western-Blot-NBP2-46576-img0002.jpg "Western Blot: cIAP-2/HIAP-1 Antibody (OTI1A9) [NBP2-46576]")
| Applications: | WB |
![Western Blot: cIAP-2/HIAP-1 Overexpression Lysate [NBL1-07986]](https://resources.bio-techne.com/images/products/cIAP2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07986-img0002.jpg "Western Blot: cIAP-2/HIAP-1 Overexpression Lysate [NBL1-07986]")
| Applications: | WB |
![Western Blot: cIAP-2/HIAP-1 Overexpression Lysate [NBL1-07985]](https://resources.bio-techne.com/images/products/cIAP2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07985-img0002.jpg "Western Blot: cIAP-2/HIAP-1 Overexpression Lysate [NBL1-07985]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
Potent Lys-covalent pan-IAP inhibitor
| Chemical Name: | (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate |
| Purity: | ≥95% (HPLC) |
Monovalent IAP antagonist
| Chemical Name: | (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide |
| Purity: | ≥97% (HPLC) |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |