Ras Products
The Ras proteins (H-Ras, N-Ras, and two splice variants of K-Ras) define a closely related family of 21 kDa GTPases that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. Receptor tyrosine kinases and G-protein coupled receptors activate Ras, and effectors include Raf and PI 3-kinase. Activating mutations of Ras, which impair GTPase activity and stabilize the active state, are found in nearly one-third of all human cancers.
23 results for "Ras" in Products
23 results for "Ras" in Products
Ras Products
The Ras proteins (H-Ras, N-Ras, and two splice variants of K-Ras) define a closely related family of 21 kDa GTPases that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. Receptor tyrosine kinases and G-protein coupled receptors activate Ras, and effectors include Raf and PI 3-kinase. Activating mutations of Ras, which impair GTPase activity and stabilize the active state, are found in nearly one-third of all human cancers.
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #342404 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Zebrafish, Xenopus, +2 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: Ras Antibody [NBP2-43784]](https://resources.bio-techne.com/images/products/Ras-Antibody-Western-Blot-NBP2-43784-img0007.jpg "Western Blot: Ras Antibody [NBP2-43784]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #HL10 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Ras Antibody (HL10)G12D Mutant [NBP3-13647]](https://resources.bio-techne.com/images/products/Ras-Antibody-HL10-G12D-Mutant-Western-Blot-NBP3-13647-img0005.jpg "Western Blot: Ras Antibody (HL10)G12D Mutant [NBP3-13647]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #HL169 |
| Applications: | IHC, WB |
![Western Blot: Ras Antibody (HL169)G12V Mutant [NBP3-13668]](https://resources.bio-techne.com/images/products/Ras-Antibody-HL169-G12V-Mutant-Western-Blot-NBP3-13668-img0007.jpg "Western Blot: Ras Antibody (HL169)G12V Mutant [NBP3-13668]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JE44-13 |
| Applications: | WB, ICC/IF, Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyG13D Mutant [NBP3-13103]](https://resources.bio-techne.com/images/products/Ras-Antibody---G13D-Mutant-Western-Blot-NBP3-13103-img0001.jpg "Western Blot: Ras AntibodyG13D Mutant [NBP3-13103]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #6J9I4 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: Ras Antibody (6J9I4) [NBP3-15909]](https://resources.bio-techne.com/images/products/Ras-Antibody-3G8L8-Western-Blot-NBP3-15909-img0003.jpg "Western Blot: Ras Antibody (6J9I4) [NBP3-15909]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #HL1153 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyG12V Mutant [NBP3-13132]](https://resources.bio-techne.com/images/products/Ras-Antibody---G12V-Mutant-Western-Blot-NBP3-13132-img0002.jpg "Western Blot: Ras AntibodyG12V Mutant [NBP3-13132]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyG12D Mutant [NBP3-13102]](https://resources.bio-techne.com/images/products/Ras-Antibody---G12D-Mutant-Western-Blot-NBP3-13102-img0002.jpg "Western Blot: Ras AntibodyG12D Mutant [NBP3-13102]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyA59T Mutant [NBP3-13100]](https://resources.bio-techne.com/images/products/Ras-Antibody---A59T-Mutant-Western-Blot-NBP3-13100-img0001.jpg "Western Blot: Ras AntibodyA59T Mutant [NBP3-13100]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyQ61R Mutant [NBP3-13101]](https://resources.bio-techne.com/images/products/Ras-Antibody---Q61R-Mutant-Western-Blot-NBP3-13101-img0001.jpg "Western Blot: Ras AntibodyQ61R Mutant [NBP3-13101]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Ras AntibodyK117N Mutant [NBP3-13104]](https://resources.bio-techne.com/images/products/Ras-Antibody---K117N-Mutant-Western-Blot-NBP3-13104-img0001.jpg "Western Blot: Ras AntibodyK117N Mutant [NBP3-13104]")
Ras signaling inhibitor; inhibits Ack1 and GCK
| Chemical Name: | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Purity: | ≥98% (HPLC) |
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
| Chemical Name: | 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent farnesyl diphosphate (FPP) synthase inhibitor
| Alternate Names: | Zometa |
| Chemical Name: | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Purity: | ≥98% (HPLC) |
Selective KRAS Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥95% (HPLC) |
Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
| Chemical Name: | N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
| Chemical Name: | 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride |
| Purity: | ≥99% (HPLC) |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% (HPLC) |
Mutation-selective inhibitor of KRASG12C
| Alternate Names: | Adagrasib |
| Chemical Name: | 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2S)-2-piperazineacetonitrile |
| Purity: | ≥98% (HPLC) |
Negative control for LC 2 (Cat. No. 7420)
| Chemical Name: | (2S,4S)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥95% (HPLC) |
PDEδ autophagy-tethering compound (ATTEC) Degrader
| Chemical Name: | N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide |
| Purity: | ≥98% (HPLC) |
