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Key Product Details

Species Reactivity

Validated:

Human

Applications

CyTOF-ready, Flow Cytometry, Functional, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # AYP1

Format

BSA Free

Concentration

1 mg/ml

Product Summary for CLEC-2/CLEC-1B Antibody (AYP1) - BSA Free

Immunogen

A recombinant extracellular fragment of human CLEC-2/CLEC-1B (aa 68-229), which is the extracellular domain of the protein

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Applications for CLEC-2/CLEC-1B Antibody (AYP1) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:10 - 1:1000

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunoprecipitation

1:10 - 1:500
Application Notes
AYP1 can block the interaction of human CLEC-2/CLEC-1B with its endogenous ligand Podoplanin. AYP1 does not cross react with mouse CLEC-2/CLEC-1B when tested via Flow Cytometry.This antibody is Cytof ready. Positive control(s): Platelets.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CLEC-2/CLEC1B

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]

Long Name

C-type Lectin-like Receptor 2

Alternate Names

CLEC1B, CLEC2

Gene Symbol

CLEC1B

Additional CLEC-2/CLEC1B Products

Product Documents for CLEC-2/CLEC-1B Antibody (AYP1) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CLEC-2/CLEC-1B Antibody (AYP1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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