Endoglin/CD105 Antibody (SN6) [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-63330

Clone SN6 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # SN6

Concentration

0.1 mg/ml

View all Endoglin/CD105 Antibodies »

Product Specifications

Immunogen

Partially purified cell membrane antigens from fresh leukemia cells

Reactivity Notes

Predicted cross-reactivities: Cynomolgus monkey, Equine, Primate, Rhesus Monkey

Specificity

Recognizes the human CD105 cell surface antigen, a glycoprotein homodimer of 95kD subunits. CD105 is also known as endoglin, and is expressed by endothelial cells, activated monocytes and some leukemia cells.

Marker

Neo-endothelial Cells Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Endoglin/CD105 Antibody (SN6) [FITC]

Flow Cytometry: Endoglin/CD105 Antibody (SN6) [FITC] [NB100-63330] - Staining of KG1 cells with MOUSE ANTI HUMAN CD105:FITC

Applications for Endoglin/CD105 Antibody (SN6) [FITC]

Application
Recommended Usage

Flow Cytometry

1:10-1:1000
Application Notes
The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. The use of acetone fixation for frozen sections is recommended.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Endoglin/CD105

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Alternate Names

CD105, ENG

Gene Symbol

ENG

UniProt

P17813

Additional Endoglin/CD105 Products

Product Documents for Endoglin/CD105 Antibody (SN6) [FITC]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Endoglin/CD105 Antibody (SN6) [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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