Integrin alpha V beta 3 Antibody (23C6) [PE/Atto594]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2677PEATT594

Novus Biologicals, part of Bio-Techne
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NB100-2677PEATT594
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry, Immunohistochemistry, Immunoprecipitation

Label

PE/Atto594 (Excitation = 488 nm, Emission = 627 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 23C6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Integrin alpha V beta 3 Antibodies »

Product Specifications

Immunogen

A cell suspension containing osteoclasts from osteoclastomas.

Localization

Cell Membrane

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Integrin alpha V beta 3 Antibody (23C6) [PE/Atto594]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: Integrin alpha V beta 3

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Alternate Names

antigen identified by monoclonal L230, CD51, CD51 antigen, integrin alpha-V, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), MSK8, Vitronectin receptor subunit alpha, VNRADKFZp686A08142

Gene Symbol

ITGAV

Additional Integrin alpha V beta 3 Products

Product Documents for Integrin alpha V beta 3 Antibody (23C6) [PE/Atto594]

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Integrin alpha V beta 3 Antibody (23C6) [PE/Atto594]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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