Mcl-1 Antibody (OTI10F6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-45773

Novus Biologicals, part of Bio-Techne
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NBP2-45773
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Conjugate
Catalog #
Alexa Fluor 350
NBP2-72598AF350
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Alexa Fluor 405
NBP2-72598AF405
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Alexa Fluor 488
NBP2-72598AF488
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Alexa Fluor 532
NBP2-72598AF532
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Alexa Fluor 594
NBP2-72598AF594
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Alexa Fluor 647
NBP2-72598AF647
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Alexa Fluor 700
NBP2-72598AF700
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Alexa Fluor 750
NBP2-72598AF750
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Allophycocyanin
NBP2-72598APC
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Allophycocyanin/Cy7
NBP2-72598APCCY7
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Biotin
NBP2-72598B
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CoraFluor 1
NBP2-72598CL1
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DyLight 350
NBP2-72598UV
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DyLight 405
NBP2-72598V
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DyLight 488
NBP2-72598G
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DyLight 550
NBP2-72598R
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DyLight 594
NBP2-72598DL594
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DyLight 650
NBP2-72598C
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DyLight 680
NBP2-72598FR
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DyLight 755
NBP2-72598IR
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FITC
NBP2-72598F
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HRP
NBP2-72598H
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Janelia Fluor 525
NBP2-72598JF525
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Janelia Fluor 549
NBP2-72598JF549
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Janelia Fluor 585
NBP2-72598JF585
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Janelia Fluor 635
NBP2-72598JF635
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Janelia Fluor 646
NBP2-72598JF646
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Janelia Fluor 669
NBP2-72598JF669
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mFluor Violet 450 SE
NBP2-72598MFV450
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mFluor Violet 500 SE
NBP2-72598MFV500
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mFluor Violet 610 SE
NBP2-72598MFV610
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PE
NBP2-72598PE
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PE/Atto594
NBP2-72598PEATT594
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PE/Cy5.5
NBP2-72598PECY55
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PE/Cy7
NBP2-72598PECY7
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PerCP
NBP2-72598PCP
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI10F6

Concentration

1 mg/ml

View all Mcl-1 Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human MCL1 (NP_068779) produced in HEK293T cell.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

37.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Mcl-1 Antibody (OTI10F6)

Western Blot: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Western Blot: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Western Blot: Mcl-1 Antibody (OTI10F6) [NBP2-45773] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MCL-1.
Immunohistochemistry: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Immunohistochemistry: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Immunohistochemistry: Mcl-1 Antibody (OTI10F6) [NBP2-45773] - Analysis of Carcinoma of prostate tissue.
Flow Cytometry: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Flow Cytometry: Mcl-1 Antibody (OTI10F6) [NBP2-45773]

Flow Cytometry: Mcl-1 Antibody (OTI10F6) [NBP2-45773] - Analysis of HEK293T cells transfected with either pCMV6-ENTRY MCL1.
View 7 more images

Applications for Mcl-1 Antibody (OTI10F6)

Application
Recommended Usage

Flow Cytometry

1:100

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:50

Immunohistochemistry-Paraffin

1:50

Western Blot

1:200 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Mcl-1

Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

Long Name

Myeloid Cell Leukemia Sequence 1

Alternate Names

BCL2L3, Mcl1

Gene Symbol

MCL1

Additional Mcl-1 Products

Product Documents for Mcl-1 Antibody (OTI10F6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Mcl-1 Antibody (OTI10F6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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