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TIMP-2 Antibody (TIMP2/8193R) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21033PE

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # TIMP2/8193R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Summary for TIMP-2 Antibody (TIMP2/8193R) [PE]

Immunogen

Recombinant fragment of human TIMP-2 protein (exact sequence is proprietary)

Localization

Cytoplasm. Cell surface.

Specificity

It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2) It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A) It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B) TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for TIMP-2 Antibody (TIMP2/8193R) [PE]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TIMP-2

The TIMP2 gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role a

Long Name

Tissue Inhibitors of Metalloproteinases 2

Alternate Names

TIMP2

Gene Symbol

TIMP2

Additional TIMP-2 Products

Product Documents for TIMP-2 Antibody (TIMP2/8193R) [PE]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TIMP-2 Antibody (TIMP2/8193R) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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