IkB-alpha Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NB120-22071PEP

Novus Biologicals, part of Bio-Techne
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NB120-22071PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all IkB-alpha Proteins and Enzymes »

Product Specifications

Description

Application Notes

This peptide is useful as a blocking peptide for NB120-22071. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NB120-22071 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB120-22071PEP
Formulation Peptide dissolved in dH20. Contains no BSA.
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: IkB-alpha

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first gene induced following NF-kB activation is IkBa.

Long Name

I-kappa-B-alpha

Alternate Names

IkBalpha, MAD-3, NFKBIA

Gene Symbol

NFKBIA

Additional IkB-alpha Products

Product Documents for IkB-alpha Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IkB-alpha Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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