AMG 21629

Name: AMG 21629
Brand: Tocris Bioscience
SKU: 4330

Tocris Bioscience, part of Bio-Techne | Catalog # 4330

Citations (3)

COA / SDS

Potent and selective TRPV1 antagonist

Key Product Details

Description:	Potent and selective TRPV1 antagonist
Chemical Name:	3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
Purity:	≥97% (HPLC)
Molecular Weight:	472.42

View Full Technical Details for AMG 21629

Technical Data
Citations

Biological Activity for AMG 21629

AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca²⁺ uptake by CHO cells expressing TRPV1 receptors (IC₅₀ values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca²⁺ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

Technical Data for AMG 21629

M. Wt	472.42
Formula	C₂₂H₁₉F₃N₆O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	939040-79-6
PubChem ID	24858024
InChi Key	TUMYQRZCVIQKOQ-UHFFFAOYSA-N
Smiles	NC(C(N4)=O)=NC(C4=CC=C3)=C3OC1=CC(C2=CC=C(C(F)(F)F)C=C2)=NC(NCCOC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 21629

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.62	50

Preparing Stock Solutions for AMG 21629

The following data is based on the product molecular weight 472.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.23 mL	21.17 mL	42.34 mL
2.5 mM	0.85 mL	4.23 mL	8.47 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
25 mM	0.08 mL	0.42 mL	0.85 mL

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References for AMG 21629

References are publications that support the biological activity of the product.

Gavva The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J.Neurosci. 2007 PMID: 17392452
Tamayo Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J.Med.Chem. 2008 PMID: 18386885