AZ 10397767

Name: AZ 10397767
Brand: Tocris Bioscience
SKU: 5872

Tocris Bioscience, part of Bio-Techne | Catalog # 5872

Citations (2)

COA / SDS

Potent CXCR2 antagonist

Key Product Details

Description:	Potent CXCR2 antagonist
Chemical Name:	5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	400.88

View Full Technical Details for AZ 10397767

Technical Data
Citations

Biological Activity for AZ 10397767

AZ 10397767 is a potent CXCR2 antagonist (IC₅₀ = 1 nM); attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of neutrophils infiltrating into tumors in both in vitro and in vivo models and delayed tumor growth. Orally bioavailable.

Compound Libraries for AZ 10397767

AZ 10397767 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 10397767

M. Wt	400.88
Formula	C₁₅H₁₄ClFN₄O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	333742-63-5
PubChem ID	11858154
InChi Key	KHTUORKUWBDRBX-SSDOTTSWSA-N
Smiles	C[C@@H](NC1=C2SC(NC2=NC(SCC3=C(C(Cl)=CC=C3)F)=N1)=O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 10397767

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.09	100

Preparing Stock Solutions for AZ 10397767

The following data is based on the product molecular weight 400.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.47 mL	24.95 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for AZ 10397767

References are publications that support the biological activity of the product.

Walters Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg.Med.Chem.Lett. 2008 PMID: 18240390
Tazzyman Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth. Int.J.Cancer 2011 PMID: 21328342
Wilson Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxalip. through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis. J.Pharmacol.Exp.Ther. 2008 PMID: 18780829