BMS 986187

Name: BMS 986187
Brand: Tocris Bioscience
SKU: 5983

Tocris Bioscience, part of Bio-Techne | Catalog # 5983

Citations (2)

COA / SDS

Potent positive allosteric modulator of δ receptors

Key Product Details

Description:	Potent positive allosteric modulator of δ receptors
Chemical Name:	3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	470.61

View Full Technical Details for BMS 986187

Technical Data
Citations

Biological Activity for BMS 986187

BMS 986187 is a potent δ-opioid receptor positive allosteric modulator (EC₅₀ = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu⁵]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.

Compound Libraries for BMS 986187

BMS 986187 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 986187

M. Wt	470.61
Formula	C₃₁H₃₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	684238-37-7
PubChem ID	17379334
InChi Key	UEKIYVKPQNKSDI-UHFFFAOYSA-N
Smiles	CC(C=CC=C1)=C1COC2=CC=C(C=C2)C3C4=C(CC(C)(C)CC4=O)OC5=C3C(CC(C)(C)C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 986187

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.41	20

Preparing Stock Solutions for BMS 986187

The following data is based on the product molecular weight 470.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.62 mL	53.12 mL	106.25 mL
1 mM	2.12 mL	10.62 mL	21.25 mL
2 mM	1.06 mL	5.31 mL	10.62 mL
10 mM	0.21 mL	1.06 mL	2.12 mL

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References for BMS 986187

References are publications that support the biological activity of the product.

Shang Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 2016 PMID: 26841170
Burford Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 2015 PMID: 25901762