Cyclosporin H

Name: Cyclosporin H
Brand: Tocris Bioscience
SKU: 6982

Tocris Bioscience, part of Bio-Techne | Catalog # 6982

Citations (3)

COA / SDS

Enhances lentiviral transduction

Key Product Details

Description:	Enhances lentiviral transduction
Chemical Name:	5-(N-Methyl-D-valine)cyclosporin A
Purity:	≥97% (HPLC)
Molecular Weight:	1202.64

View Full Technical Details for Cyclosporin H

Technical Data
Citations

Biological Activity for Cyclosporin H

Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E₂ (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).

Technical Data for Cyclosporin H

M. Wt	1202.64
Formula	C₆₂H₁₁₁N₁₁O₁₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	83602-39-5
PubChem ID	6476564
InChi Key	PMATZTZNYRCHOR-JLPRAAIDSA-N
Smiles	[H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclosporin H

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	120.26	100
	ethanol	60.13	50

Preparing Stock Solutions for Cyclosporin H

The following data is based on the product molecular weight 1202.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.83 mL	4.16 mL	8.32 mL
5 mM	0.17 mL	0.83 mL	1.66 mL
10 mM	0.08 mL	0.42 mL	0.83 mL
50 mM	0.02 mL	0.08 mL	0.17 mL

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Reconstitution Calculator

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References for Cyclosporin H

References are publications that support the biological activity of the product.

Petrillo Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 2018 PMID: 30416070