EML 425

Name: EML 425
Brand: Tocris Bioscience
SKU: 5646

Tocris Bioscience, part of Bio-Techne | Catalog # 5646

Citations (2)

COA / SDS

Reversible and non-competitive CBP/p300 inhibitor

Key Product Details

Description:	Reversible and non-competitive CBP/p300 inhibitor
Chemical Name:	5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Purity:	≥98% (HPLC)
Molecular Weight:	440.49

View Full Technical Details for EML 425

Technical Data
Citations

Biological Activity for EML 425

EML 425 is a reversible and non-competitive CBP/p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively). Cell permeable.

Compound Libraries for EML 425

EML 425 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EML 425

M. Wt	440.49
Formula	C₂₇H₂₄N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1675821-32-5
PubChem ID	91826273
InChi Key	LUGQBJDYUPNAQQ-UHFFFAOYSA-N
Smiles	CC1=C(/C=C2C(N(CC3=CC=CC=C3)C(N(CC4=CC=CC=C4)C\2=O)=O)=O)C(C)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EML 425

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.05	100

Preparing Stock Solutions for EML 425

The following data is based on the product molecular weight 440.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.70 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for EML 425

References are publications that support the biological activity of the product.

Milite A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 2015 PMID: 25730130