iP300v

Name: iP300v
Brand: Tocris Bioscience
SKU: 7584

Tocris Bioscience, part of Bio-Techne | Catalog # 7584

COA / SDS

Negative control for iP300w (Cat. No. 7270)

Key Product Details

Description:	Negative control for iP300w (Cat. No. 7270)
Chemical Name:	(1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	618.55

View Full Technical Details for iP300v

Technical Data
Citations

Biological Activity for iP300v

iP300v is a negative control for iP300w (Cat. No. 7270)

Technical Data for iP300v

M. Wt	618.55
Formula	C₂₉H₂₇F₅N₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2763218-94-4
InChi Key	SWXCHCQCWFXILM-YRTQXHIJSA-N
Smiles	O=C(NC)CN(N=C1)C=C1C(C=C2)=CC3=C2[C@](N4)(C[C@@H]3F)C(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for iP300v

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	61.85	100

Preparing Stock Solutions for iP300v

The following data is based on the product molecular weight 618.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.62 mL	8.08 mL	16.17 mL
5 mM	0.32 mL	1.62 mL	3.23 mL
10 mM	0.16 mL	0.81 mL	1.62 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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Reconstitution Calculator

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References for iP300v

References are publications that support the biological activity of the product.

Bosnakovski Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis
Bosnakovski A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Sci.Adv. 2019 PMID: 31535023