L-161,982

Name: L-161,982
Brand: Tocris Bioscience
SKU: 2514
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2514

Citations (27)

COA / SDS

Selective EP4 receptor antagonist

Key Product Details

Description:	Selective EP₄ receptor antagonist
Chemical Name:	N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	654.72

View Full Technical Details for L-161,982

Technical Data
Citations

Biological Activity for L-161,982

L-161,982 is an EP₄ receptor antagonist that is selective over all other members of the prostanoid receptor family (K_i values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP₄, TP, EP₃, DP, FP, IP, EP₁ and EP₂ receptors respectively). Suppresses PGE₂-induced bone formation in rats and prevents the nociceptive response induced by Misoprostol (Cat. No. 2297) in formalin-injected mice.

Compound Libraries for L-161,982

L-161,982 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-161,982

M. Wt	654.72
Formula	C₃₂H₂₉F₃N₄O₄S₂
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	147776-06-5
PubChem ID	9961192
InChi Key	MMDNKTXNUZFVKD-UHFFFAOYSA-N
Smiles	CCCCC1=NN(C(=O)N1CC1=CC=C(C=C1)C1=C(C=CC=C1)S(=O)(=O)NC(=O)C1=C(C)C=CS1)C1=C(C=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-161,982

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	65.47	100

Preparing Stock Solutions for L-161,982

The following data is based on the product molecular weight 654.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.64 mL	15.27 mL
5 mM	0.31 mL	1.53 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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References for L-161,982

References are publications that support the biological activity of the product.

Oliva Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. Eur.J.Pharmacol. 2006 PMID: 16360148
Balzary Lipopolysaccharide induces epithelium- and prostaglandin E₂-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2. J.Pharmacol.Exp.Ther. 2006 PMID: 16464966
Machwate Prostaglandin receptor EP₄ mediates the bone anabolic effects of PGE₂. Mol.Pharmacol. 2001 PMID: 11408598