LDN 193189 in solution

Name: LDN 193189 in solution
Brand: Tocris Bioscience
SKU: 8150

Tocris Bioscience, part of Bio-Techne | Catalog # 8150

COA / SDS

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Key Product Details

Description:	Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
Chemical Name:	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	479.41

View Full Technical Details for LDN 193189 in solution

Technical Data
Citations

Biological Activity for LDN 193189 in solution

LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of LDN 193189 pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC₅₀ values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484

Technical Data for LDN 193189 in solution

M. Wt	479.41
Formula	C₂₅H₂₂N₆.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1435934-00-1
InChi Key	CMQXLLAILGGLRV-UHFFFAOYSA-N
Smiles	N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LDN 193189 in solution

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for LDN 193189 in solution

References are publications that support the biological activity of the product.

Lancaster Generation of cerebral organoids from human pluripotent stem cells. Nat.Protoc. 2015 PMID: 25188634
Li Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 2013 PMID: 24012368
Chambers Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 2012 PMID: 22750882
Cuny Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18621530
Yu BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 2008 PMID: 19029982

Product Documents for LDN 193189 in solution

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.