PSC 833

Name: PSC 833
Brand: Tocris Bioscience
SKU: 4042
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4042

(1)

Citations (30)

COA / SDS

Inhibitor of P-gp-mediated MDR

Key Product Details

Description:	Inhibitor of P-gp-mediated MDR
Alternative Names:	Valspodar
Chemical Name:	6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
Purity:	≥98% (HPLC)
Molecular Weight:	1214.62

View Full Technical Details for PSC 833

Technical Data
Citations / Reviews (1)

Biological Activity for PSC 833

PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Technical Data for PSC 833

M. Wt	1214.62
Formula	C₆₃H₁₁₁N₁₁O₁₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	121584-18-7
PubChem ID	5281884
InChi Key	YJDYDFNKCBANTM-QCWCSKBGSA-N
Smiles	C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSC 833

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2

Preparing Stock Solutions for PSC 833

The following data is based on the product molecular weight 1214.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	41.17 mL	205.83 mL	411.65 mL
0.1 mM	8.23 mL	41.17 mL	82.33 mL
0.2 mM	4.12 mL	20.58 mL	41.17 mL
1 mM	0.82 mL	4.12 mL	8.23 mL

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References for PSC 833

References are publications that support the biological activity of the product.

Shen Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 2009 PMID: 19423841
Goda Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 2007 PMID: 17050779
Shen Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 2008 PMID: 17947497
Song Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 1998 PMID: 9864280