Ro 8-4304 hydrochloride

Name: Ro 8-4304 hydrochloride
Brand: Tocris Bioscience
SKU: 3343

Tocris Bioscience, part of Bio-Techne | Catalog # 3343

COA / SDS

GluN2B-selective NMDA antagonist

Discontinued Product

3343 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description:	GluN2B-selective NMDA antagonist
Chemical Name:	4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	406.88

View Full Technical Details for Ro 8-4304 hydrochloride

Technical Data
Citations

Biological Activity for Ro 8-4304 hydrochloride

NMDA receptor antagonist (IC₅₀ = 0.4 μM) that displays > 100 fold selectivity for GluN2B (formally NR2B) containing receptors over GluN2A (formally NR2A) containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for Ro 8-4304 hydrochloride

M. Wt	406.88
Formula	C₂₁H₂₃FN₂O₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1312991-77-7
PubChem ID	11957680
InChi Key	MQOXWHKUQOFFJW-UHFFFAOYSA-N
Smiles	NC(C1=CC=C(OCC(O)CN2CCC(C3=CC=C(F)C=C3)=CC2)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ro 8-4304 hydrochloride

References are publications that support the biological activity of the product.

Kew and Kemp An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 1998 PMID: 9729614
Kew State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 1998 PMID: 9504387

Ro 8-4304 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3343

Key Product Details

Biological Activity for Ro 8-4304 hydrochloride

Technical Data for Ro 8-4304 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ro 8-4304 hydrochloride

Product Documents for Ro 8-4304 hydrochloride

COA

Certificate of Analysis

SDS

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