Tariquidar dihydrochloride

Name: Tariquidar dihydrochloride
Brand: Tocris Bioscience
SKU: 5757

Tocris Bioscience, part of Bio-Techne | Catalog # 5757

Citations (1)

COA / SDS

Potent P-glycoprotein (P-gp) inhibitor

Key Product Details

Description:	Potent P-glycoprotein (P-gp) inhibitor
Chemical Name:	N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	719.66

View Full Technical Details for Tariquidar dihydrochloride

Technical Data
Citations

Biological Activity for Tariquidar dihydrochloride

Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC₅₀ = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.

Compound Libraries for Tariquidar dihydrochloride

Tariquidar dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tariquidar dihydrochloride

M. Wt	719.66
Formula	C₃₈H₃₈N₄O₆.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1992047-62-7
PubChem ID	121513890
InChi Key	ZJCJRGRTDKIFJJ-UHFFFAOYSA-N
Smiles	O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tariquidar dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.98	50

Preparing Stock Solutions for Tariquidar dihydrochloride

The following data is based on the product molecular weight 719.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.90 mL	27.79 mL
2.5 mM	0.56 mL	2.78 mL	5.56 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for Tariquidar dihydrochloride

References are publications that support the biological activity of the product.

Loo Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 2015 PMID: 26507655
Kannan The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2011 PMID: 22778859