WM 3835

Name: WM 3835
Brand: Tocris Bioscience
SKU: 7366

Tocris Bioscience, part of Bio-Techne | Catalog # 7366

Citations (2)

COA / SDS

Lysine acetyltransferase HBO1 (KAT7) inhibitor

Key Product Details

Description:	Lysine acetyltransferase HBO1 (KAT7) inhibitor
Chemical Name:	N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	400.42

View Full Technical Details for WM 3835

Technical Data
Citations

Biological Activity for WM 3835

WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.

Compound Libraries for WM 3835

WM 3835 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WM 3835

M. Wt	400.42
Formula	C₂₀H₁₇FN₂O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229025-70-9
PubChem ID	134581412
InChi Key	KVJFJJXCBRSCDY-UHFFFAOYSA-N
Smiles	CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WM 3835

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.04	100
	ethanol	20.02	50

Preparing Stock Solutions for WM 3835

The following data is based on the product molecular weight 400.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for WM 3835

References are publications that support the biological activity of the product.

MacPherson HBO1 is required for the maintenance of leukaemia stem cells. Nature 2019 PMID: 31827282