WM 8014

Name: WM 8014
Brand: Tocris Bioscience
SKU: 6693

Tocris Bioscience, part of Bio-Techne | Catalog # 6693

COA / SDS

Potent and selective KAT6A and KAT6B inhibitor

Key Product Details

Description:	Potent and selective KAT6A and KAT6B inhibitor
Chemical Name:	N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	384.42

View Full Technical Details for WM 8014

Technical Data
Citations

Biological Activity for WM 8014

WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC₅₀ values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G₁/G₀ in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.

Licensing Information

Sold under license from Monash University

Compound Libraries for WM 8014

WM 8014 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WM 8014

M. Wt	384.42
Formula	C₂₀H₁₇FN₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2055397-18-5
PubChem ID	133053564
InChi Key	PHHZKBMVRPULAW-UHFFFAOYSA-N
Smiles	CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC=CC=C3)=O)=O)=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WM 8014

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.69	20
	ethanol	3.84	10

Preparing Stock Solutions for WM 8014

The following data is based on the product molecular weight 384.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.01 mL	65.03 mL	130.07 mL
1 mM	2.60 mL	13.01 mL	26.01 mL
2 mM	1.30 mL	6.50 mL	13.01 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

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References for WM 8014

References are publications that support the biological activity of the product.

Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 2018 PMID: 30069049