Zosuquidar trihydrochloride

Name: Zosuquidar trihydrochloride
Brand: Tocris Bioscience
SKU: 5456

Tocris Bioscience, part of Bio-Techne | Catalog # 5456

Citations (3)

COA / SDS

High affinity P-gp inhibitor

Key Product Details

Description:	High affinity P-gp inhibitor
Alternative Names:	LY 335979
Chemical Name:	(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	636.99

View Full Technical Details for Zosuquidar trihydrochloride

Technical Data
Citations

Biological Activity for Zosuquidar trihydrochloride

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (K_d = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Compound Libraries for Zosuquidar trihydrochloride

Zosuquidar trihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zosuquidar trihydrochloride

M. Wt	636.99
Formula	C₃₂H₃₁F₂N₃O₂.3HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	167465-36-3
PubChem ID	153997
InChi Key	ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Smiles	F[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zosuquidar trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.85	50

Preparing Stock Solutions for Zosuquidar trihydrochloride

The following data is based on the product molecular weight 636.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.14 mL	15.70 mL	31.40 mL
2.5 mM	0.63 mL	3.14 mL	6.28 mL
5 mM	0.31 mL	1.57 mL	3.14 mL
25 mM	0.06 mL	0.31 mL	0.63 mL

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References for Zosuquidar trihydrochloride

References are publications that support the biological activity of the product.

Dantzig Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 1996 PMID: 8797588
Dantzig Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 1999 PMID: 10411602