Key Features | Product Formats | Biomarker Discovery and Validation | Professional Assay Services
Measure RNA Biomarkers with Spatial Context from Translational to Clinical Applications
Leverage the unrivaled sensitivity and specificity of RNAscope™ ISH technology for spatial visualization of biomarkers. RNAscope™ ISH enables measurement of RNA biomarkers with spatial context from translational to clinical applications. The technology also overcomes antibody development challenges for neoantigens, TCR targets, homologous genes and can be used to qualify biomarkers for disease progression, patient stratification and clinical endpoints with high precision.
Key Features:
- Validate and quantitate target candidates based on disease, region- and species-specific expression.
- Screen biomarkers for tissue-specific gene expression with our high throughput assays.
- Combine multiple cell-specific marker probes in heterogenous tissue microenvironments or signaling pathways.
- Co-detect RNA and protein markers for multiomic analysis; compatible with latest automation solutions.
- Measure therapeutic response by evaluating RNA markers as clinical endpoints.
RNAscope Assays for Complex Biomarkers
Detect multiple types of RNA biomarkers for various applications.
RNAscope ISH Product Formats
RNAscope ISH is a universal technology for use on any sample type including FFPE, fresh frozen, fresh fixed cell and tissues and more.
RNAscope~20 ZZ probe pairs Designed to > 300 nt.
| BaseScope™1-3 ZZ probe pairs Designed to ~ 50-300 nt.
| miRNAscope™Designed to ~17-50 nt.
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Early Discovery and Biomarker Validation
Gain access to tissue banks for early discovery and screening in any species of interest by partnering with Professional Assay Services (PAS). Our experts in RNAscope technology will work with you to validate target expression patterns in normal and diseased tissue.
Biomarker Expression Validation
Screen candidate targets and confirm presence on tissue(s) and species of interest. RNAscope single-plex assay was used to assess the expression of a gene that is involved in fatty acid production. Data demonstrated the comparison of target expression across multiple liver samples from both human and non-human primate tissues predicting cross species biological differences that can inform experimental design and even toxicology data interpretation at later stages.
Disease Validation
Validate candidate targets based on disease- and region-specific expression. Representative images from a normal and a Crohn’s disease tissue from our tissue bank. RNAscope technology can be used to identify changes in target expression patterns in the disease state or even across different stages of a disease. We offer access to tissues for multiple disease indications for our customers.
Professional Assay Services offers you direct access to the developers of RNAscope in situ hybridization (ISH) technology. Accelerate your journey in target validation, pre-clinical, and clinical development with the promise that we will provide consistent and trustworthy data to drive your projects forward.
Probe Design with Unmatched Specificity
Select just the genes you want from an extensive online catalog and custom design services. We offer ultimate flexibility in RNAscope probe design. Easily design probes specific to your target for use in any animal model system.
Automation Solutions
Our automated assays are compatible with leading instruments including the Leica Biosystems, Roche and Lunaphore systems. Choose from chromogenic or fluorescent read-outs and purchase bulk-reagents with established protocols compatible with these systems.
Clinical Assay Development
Partner with our Professional Assay Services (PAS) to develop assays for your target biomarkers and advance your assay to identify patients with disease relevant biomarkers.
Webinar: Accelerate Spatial Visualization for Target Identification and Validation using RNAscope ISH Services
Watch this webinar to learn how our Professional Assay Services (PAS) can partner with you to accelerate your preclinical to clinical programs with flexible and scalable multiomic services.
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