AIF-1/Iba1 Products
Allograft-Inflammatory Factor 1 (AIF-1), also known as Ionized Calcium-Binding Adapter Molecule 1 (Iba1) and Diantain, is a macrophage/microglia-specific calcium-binding protein. Human AIF-1/Iba1 is 147 amino acids (aa) in length with a predicted molecule weight of approximately 17 kDa. This cytoplasmic protein contains two calcium-binding EF-hand motifs at aa 45-80 and 81-115. Alternative splicing produces a second isoform, which lacks the first 54 N-terminal aa, and a third isoform that lacks aa 1-54, as well as aa 121-147, but also has a 66 aa insertion at position 65. Human AIF-1/Iba1 shares 89% aa sequence identity with the mouse and rat orthologs.
AIF-1/Iba1 expression in macrophages and microglia is upregulated during the activation of these cells. It is important for the proinflammatory response to ischemia, tissue injury, and atherosclerosis. AIF-1/Iba1 is also expressed in vascular smooth muscle and endothelial cells, where it promotes vascular remodeling and new vessel formation. Additionally, AIF-1/Iba1 is upregulated in allografted tissue during transplant rejection and promotes the proliferation of breast cancer cells and in vivo tumorigenesis.
149 results for "AIF-1/Iba1" in Products
149 results for "AIF-1/Iba1" in Products
AIF-1/Iba1 Products
Allograft-Inflammatory Factor 1 (AIF-1), also known as Ionized Calcium-Binding Adapter Molecule 1 (Iba1) and Diantain, is a macrophage/microglia-specific calcium-binding protein. Human AIF-1/Iba1 is 147 amino acids (aa) in length with a predicted molecule weight of approximately 17 kDa. This cytoplasmic protein contains two calcium-binding EF-hand motifs at aa 45-80 and 81-115. Alternative splicing produces a second isoform, which lacks the first 54 N-terminal aa, and a third isoform that lacks aa 1-54, as well as aa 121-147, but also has a 66 aa insertion at position 65. Human AIF-1/Iba1 shares 89% aa sequence identity with the mouse and rat orthologs.
AIF-1/Iba1 expression in macrophages and microglia is upregulated during the activation of these cells. It is important for the proinflammatory response to ischemia, tissue injury, and atherosclerosis. AIF-1/Iba1 is also expressed in vascular smooth muscle and endothelial cells, where it promotes vascular remodeling and new vessel formation. Additionally, AIF-1/Iba1 is upregulated in allografted tissue during transplant rejection and promotes the proliferation of breast cancer cells and in vivo tumorigenesis.
| Reactivity: | Human, Mouse, Rat, Canine, Porcine, +2 More |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, IP, +3 More |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody (rAIF1/1909) [NBP2-75755]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-rAIF1-1909-Immunohistochemistry-Paraffin-NBP2-75755-img0001.jpg "Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody (rAIF1/1909) [NBP2-75755]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rAIF1/1909 |
| Applications: | IHC, MA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #AIF1/8970R |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat, Primate - Macaca mulatta (Rhesus Macaque) |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow, B/N, +1 More |
![Western Blot: AIF-1/Iba1 Antibody [NBP2-19019]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-Western-Blot-NBP2-19019-img0014.jpg "Western Blot: AIF-1/Iba1 Antibody [NBP2-19019]")
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Immunocytochemistry/ Immunofluorescence: AIF-1/Iba1 Antibody [NB100-2833]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2833-img0015.jpg "Immunocytochemistry/ Immunofluorescence: AIF-1/Iba1 Antibody [NB100-2833]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #603102 |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Immunoprecipitation: AIF-1/Iba1 Antibody [NBP2-16908]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-Immunoprecipitation-NBP2-16908-img0018.jpg "Immunoprecipitation: AIF-1/Iba1 Antibody [NBP2-16908]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #HL22 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: AIF-1/Iba1 Antibody (HL22) [NBP3-13648]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-HL22-Western-Blot-NBP3-13648-img0010.jpg "Western Blot: AIF-1/Iba1 Antibody (HL22) [NBP3-13648]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JM36-62 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: AIF-1/Iba1 Antibody (JM36-62) [NBP2-75397]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-JM36-62-Western-Blot-NBP2-75397-img0008.jpg "Western Blot: AIF-1/Iba1 Antibody (JM36-62) [NBP2-75397]")
| Reactivity: | Human, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF, Flow |
![Immunocytochemistry/ Immunofluorescence: AIF-1/Iba1 Antibody [NBP1-06014]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-06014-img0009.jpg "Immunocytochemistry/ Immunofluorescence: AIF-1/Iba1 Antibody [NBP1-06014]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody [NBP2-14276]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-Immunohistochemistry-Paraffin-NBP2-14276-img0001.jpg "Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody [NBP2-14276]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #031 |
| Applications: | IHC, ELISA, ICC/IF |
![Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody (031) [NBP2-90271]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-031-Immunohistochemistry-Paraffin-NBP2-90271-img0002.jpg "Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody (031) [NBP2-90271]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #145 |
| Applications: | WB, ELISA, IP |
![Western Blot: AIF-1/Iba1 Antibody (145) [NBP2-90272]](https://resources.bio-techne.com/images/products/AIF-1-Iba1-Antibody-145-Western-Blot-NBP2-90272-img0001.jpg "Western Blot: AIF-1/Iba1 Antibody (145) [NBP2-90272]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR1261 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL10936 |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody [NBP3-21185] -](https://resources.bio-techne.com/images/products/nbp3-21185_mouse-aif-1-iba1-mab-cl10936-45202315531387.jpg "Immunohistochemistry-Paraffin: AIF-1/Iba1 Antibody [NBP3-21185] -")