Aminopeptidase P2/XPNPEP2: Proteins and Enzymes

The human XPNPEP2 gene encodes aminopeptidase P2 (APP2), which is also known as X-prolyl aminopeptidase 2 or membrane bound aminopeptidase P. Aminopeptidase P2 is a member of the M24 family of metalloproteases, which also contains methionine aminopeptidases, X-Pro dipeptidase, aminopeptidase P1, aminopeptidase P homolog, proliferation-associated protein 1, and suppressor of Ty homolog or chromatin-specific transcription elongation factor large subunit. Mammalian Aminopeptidase P2 are predicted to be GPI-anchored membrane proteases. Human APP2 is widely expressed in many adult tissues with the highest levels in the kidney.