ATM Products
Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.
26 results for "ATM" in Products
26 results for "ATM" in Products
ATM Products
Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.
| Reactivity: | Human, Mouse, Rat, Monkey, Hamster - Cricetulus (Chinese Hamster) |
| Details: | Mouse IgG1 Monoclonal Clone #2C1 |
| Applications: | IHC, WB, ICC/IF, ELISA, Flow, +6 More |
![Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309]](https://resources.bio-techne.com/images/products/ATM-Antibody-2C1-Immunohistochemistry-Paraffin-NB100-309-img0011.jpg "Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309]")
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP, B/N |
| Reactivity: | Human, Mouse, Rat, Monkey, Avian - Chicken |
| Details: | Mouse IgG1 Monoclonal Clone #5C2 |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: ATM Antibody (5C2) [NB100-220]](https://resources.bio-techne.com/images/products/ATM-Antibody-5C2-Western-Blot-NB100-220-img0007.jpg "Western Blot: ATM Antibody (5C2) [NB100-220]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #664703 |
| Applications: | ICC |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine (Negative) |
| Details: | Mouse IgG1 kappa Monoclonal Clone #10H11.E12 |
| Applications: | IHC, WB, ICC/IF, IP |