CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
6 results for "CTLA-4" in Products
6 results for "CTLA-4" in Products
CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
| Source: | CHO |
| Accession #: | P16410 |
| Applications: | BA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q6GR94 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q6GTR6 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #BNI3 |
| Applications: | IHC, ICC/IF, ELISA, Flow, IP |
![CTLA-4 Antibody (BNI3) ELISA: CTLA-4 Antibody (BNI3) [NB100-64849] -](https://resources.bio-techne.com/images/products/nb100-64849_mouse-monoclonal-ctla-4-antibody-bni3-2312025235988.jpg "ELISA: CTLA-4 Antibody (BNI3) [NB100-64849] -")
| Applications: | ELISA |
![ELISA: Human CTLA-4 ELISA Kit (Colorimetric) [NBP1-91268]](https://resources.bio-techne.com/images/products/CTLA-4-ELISA-Kit-ELISA-NBP1-91268-img0001.jpg "ELISA: Human CTLA-4 ELISA Kit (Colorimetric) [NBP1-91268]")