gp130 Products
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
6 results for "gp130" in Products
6 results for "gp130" in Products
gp130 Products
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #28105 |
| Applications: | IHC, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #28126 |
| Applications: | Flow, CyTOF-ready, Neut |
| Source: | NS0 |
| Accession #: | P40189 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #125605 |
| Applications: | Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Source: | NS0 |
| Accession #: | EDM10349 |
| Applications: | BA |