GSK-3 alpha Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimers disease, bipolar disorder, and cancer.
68 results for "GSK-3 alpha" in Products
68 results for "GSK-3 alpha" in Products
GSK-3 alpha Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimers disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% (HPLC) |
CHIR 99021 synthesized to cGMP guidelines
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥99% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #288901 |
| Applications: | ICC |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #4I10Q9 |
| Applications: | WB, IP, KO |
![Western Blot: GSK-3 alpha Antibody (4I10Q9) [NBP3-15639]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-4I10Q9-Western-Blot-NBP3-15639-img0003.jpg "Western Blot: GSK-3 alpha Antibody (4I10Q9) [NBP3-15639]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
![Immunocytochemistry/ Immunofluorescence: GSK-3 alpha Antibody [NBP2-97994]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-97994-img0001.jpg "Immunocytochemistry/ Immunofluorescence: GSK-3 alpha Antibody [NBP2-97994]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #9D5G1 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: GSK-3 alpha Antibody (9D5G1)BSA Free [NB110-87048]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-9D5G1-Western-Blot-NB110-87048-img0008.jpg "Western Blot: GSK-3 alpha Antibody (9D5G1)BSA Free [NB110-87048]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, KO |
![Western Blot: GSK-3 alpha AntibodyAzide and BSA Free [NBP3-15579]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-Western-Blot-NBP3-15579-img0002.jpg "Western Blot: GSK-3 alpha AntibodyAzide and BSA Free [NBP3-15579]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: GSK-3 alpha Antibody [NBP1-87445]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-Western-Blot-NBP1-87445-img0004.jpg "Western Blot: GSK-3 alpha Antibody [NBP1-87445]")
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S07-3A2 |
| Applications: | WB |
![Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-S07-3A2-Western-Blot-NBP3-15036-img0001.jpg "Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SBGSK3a1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SBGSK3a2 |
| Applications: | WB |
| Applications: | AC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #4A5 |
| Applications: | IHC, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #6G12C2 |
| Applications: | WB, ELISA |
![Western Blot: GSK-3 alpha Antibody (6G12C2)BSA Free [NB110-87049]](https://resources.bio-techne.com/images/products/GSK-3-alpha-Antibody-6G12C2-Western-Blot-NB110-87049-img0003.jpg "Western Blot: GSK-3 alpha Antibody (6G12C2)BSA Free [NB110-87049]")
| Applications: | WB |
![Western Blot: GSK-3 alpha Overexpression Lysate [NBL1-11361]](https://resources.bio-techne.com/images/products/GSK3-alpha-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-11361-img0002.jpg "Western Blot: GSK-3 alpha Overexpression Lysate [NBL1-11361]")
| Applications: | ELISA |
| Applications: | ELISA |
