Hyaluronidase 4/HYAL4: Proteins and Enzymes
Hyaluronidases (HYALs) are a group of five endo beta N-acetyl hexosaminidases that include HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1/PH20. HYAL1, HYAL2 and SPAM1 are endo beta N-acetyl glucosaminidases that are primarily active on hyaluronan, while HYAL4 is primarily active on chondroitin sulfate (type C and D in particular).
The backbone of chondroitin sulfate is composed of repeating units of -4GlcA beta 1-3 GalNAc beta 1-, and it most closely resembles that of hyaluronan (repeating units of -4GlcA beta 1-3 GlcNAc beta 1-). HYAL4 is believed to specifically degrade chondroitin sulfate in the lysosome, as its optimal pH for activity is approximately 4.5.
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Hyaluronidase 4/HYAL4: Proteins and Enzymes
Hyaluronidases (HYALs) are a group of five endo beta N-acetyl hexosaminidases that include HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1/PH20. HYAL1, HYAL2 and SPAM1 are endo beta N-acetyl glucosaminidases that are primarily active on hyaluronan, while HYAL4 is primarily active on chondroitin sulfate (type C and D in particular).
The backbone of chondroitin sulfate is composed of repeating units of -4GlcA beta 1-3 GalNAc beta 1-, and it most closely resembles that of hyaluronan (repeating units of -4GlcA beta 1-3 GlcNAc beta 1-). HYAL4 is believed to specifically degrade chondroitin sulfate in the lysosome, as its optimal pH for activity is approximately 4.5.
| Source: | CHO |
| Accession #: | NP_036401 |
| Applications: | EnzAct |
| Applications: | AC |