IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
100 results for "IGFBP-3" in Products
100 results for "IGFBP-3" in Products
IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Sensitivity: | 0.14 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma) |
| Sensitivity: | 16 pg/mL |
| Applications: | ELISA |
| Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, EDTA Plasma) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #84728 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Source: | NS0 |
| Accession #: | CAA46087 |
| Applications: | BA |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | CAA57271.1 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #138202 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Immunohistochemistry-Frozen: IGFBP-3 Antibody [NBP2-16933]](https://resources.bio-techne.com/images/products/IGFBP-3-Antibody-Immunohistochemistry-Frozen-NBP2-16933-img0002.jpg "Immunohistochemistry-Frozen: IGFBP-3 Antibody [NBP2-16933]")
Sf 9 (baculovirus)-expressed
| Source: | Sf 9 (baculovirus) |
| Accession #: | P17936 |
| Applications: | BA |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: IGFBP-3 Antibody [H00003486-D01P]](https://resources.bio-techne.com/images/products/IGFBP-3-Antibody-Immunocytochemistry-Immunofluorescence-H00003486-D01P-img0003.jpg "Immunocytochemistry/ Immunofluorescence: IGFBP-3 Antibody [H00003486-D01P]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: IGFBP-3 Antibody [NBP1-00203]](https://resources.bio-techne.com/images/products/IGFBP-3-Antibody-Western-Blot-NBP1-00203-img0002.jpg "Western Blot: IGFBP-3 Antibody [NBP1-00203]")
| Applications: | WB |
![Western Blot: IGFBP-3 Overexpression Lysate [NBP2-08719]](https://resources.bio-techne.com/images/products/IGFBP3-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-08719-img0001.jpg "Western Blot: IGFBP-3 Overexpression Lysate [NBP2-08719]")
| Reactivity: | Mouse |
| Details: | Rat IgG2 Monoclonal Clone #RM0096-11B16 |
| Applications: | WB |
![Western Blot: IGFBP-3 Antibody (RM0096-11B16)Azide and BSA Free [NBP1-22452]](https://resources.bio-techne.com/images/products/IGFBP-3-Antibody-RM0096-11B16-Western-Blot-NBP1-22452-img0001.jpg "Western Blot: IGFBP-3 Antibody (RM0096-11B16)Azide and BSA Free [NBP1-22452]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0342-6U23 |
| Applications: | IHC, WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2 Monoclonal Clone #RM0096-11B16 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0342-6U23 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG2 Monoclonal Clone #MM0342-6U23 |
| Applications: | IHC, WB |