Lgr6: Proteins and Enzymes

Lgr6 is a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. Lgr6 is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. In humans, Lgr6 is phosphorylated upon DNA damage, probably by ATM or ATR.