PAK1 Products
PAK (p21-activated kinases) are a family of serine/threonine kinases within the STE ser/thr protein kinase superfamily that play roles in various oncogenic signaling pathways. Cytoskeletal remodeling, motility, proliferation, and aberrant response to apoptosis and mitosis signals are among oncogenic cell functions coordinated by PAK family members. Group I (PAK1, PAK2 and PAK3, also called alpha, gamma and beta, respectively) contain auto-inhibitory and SH3 domains, in addition to the p21-binding and kinase domains present in Group II (PAK4, PAK6 and PAK7).
47 results for "PAK1" in Products
47 results for "PAK1" in Products
PAK1 Products
PAK (p21-activated kinases) are a family of serine/threonine kinases within the STE ser/thr protein kinase superfamily that play roles in various oncogenic signaling pathways. Cytoskeletal remodeling, motility, proliferation, and aberrant response to apoptosis and mitosis signals are among oncogenic cell functions coordinated by PAK family members. Group I (PAK1, PAK2 and PAK3, also called alpha, gamma and beta, respectively) contain auto-inhibitory and SH3 domains, in addition to the p21-binding and kinase domains present in Group II (PAK4, PAK6 and PAK7).
Potent and selective PAK1 inhibitor
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide |
| Purity: | ≥98% (HPLC) |
Negative control of NVS PAK1 1 (Cat. No. 6132)
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: PAK1 Antibody [NBP2-19680]](https://resources.bio-techne.com/images/products/PAK1-Antibody-Western-Blot-NBP2-19680-img0007.jpg "Western Blot: PAK1 Antibody [NBP2-19680]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 kappa Monoclonal Clone #4D1 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: PAK1 Antibody (4D1) [H00005058-M02]](https://resources.bio-techne.com/images/products/PAK1-Antibody-4D1-Western-Blot-H00005058-M02-img0011.jpg "Western Blot: PAK1 Antibody (4D1) [H00005058-M02]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunohistochemistry-Paraffin: PAK1 Antibody [NBP1-85802]](https://resources.bio-techne.com/images/products/PAK1-Antibody-Immunohistochemistry-Paraffin-NBP1-85802-img0016.jpg "Immunohistochemistry-Paraffin: PAK1 Antibody [NBP1-85802]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | ICC |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2113 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #4F10 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: PAK1 Antibody (4F10) [NBP3-15141]](https://resources.bio-techne.com/images/products/PAK1-Antibody-4F10-Western-Blot-NBP3-15141-img0002.jpg "Western Blot: PAK1 Antibody (4F10) [NBP3-15141]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: PAK1 AntibodyBSA Free [NBP3-04201]](https://resources.bio-techne.com/images/products/PAK1-Antibody-Western-Blot-NBP3-04201-img0003.jpg "Western Blot: PAK1 AntibodyBSA Free [NBP3-04201]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #6R3M5 |
| Applications: | WB, ICC/IF |
![Western Blot: PAK1 Antibody (6R3M5) [NBP3-15811]](https://resources.bio-techne.com/images/products/PAK1-Antibody-6R3M5-Western-Blot-NBP3-15811-img0002.jpg "Western Blot: PAK1 Antibody (6R3M5) [NBP3-15811]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: PAK1 Antibody [NB100-41389]](https://resources.bio-techne.com/images/products/PAK1-Antibody-Western-Blot-NB100-41389-img0001.jpg "Western Blot: PAK1 Antibody [NB100-41389]")
| Applications: | WB, ELISA, MA, AP |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: PAK1 AntibodyBSA Free [NBP2-95108]](https://resources.bio-techne.com/images/products/PAK1 "Western Blot: PAK1 AntibodyBSA Free [NBP2-95108]")
| Applications: | WB, ELISA, MA, AP, PAGE |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: PAK1 [p Thr84] Antibody [NBP2-29511]](https://resources.bio-techne.com/images/products/PAK1-[p-Thr84]-Antibody-Western-Blot-NBP2-29511-img0002.jpg "Western Blot: PAK1 [p Thr84] Antibody [NBP2-29511]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: PAK1 [p Ser204] Antibody [NBP2-29665]](https://resources.bio-techne.com/images/products/PAK1-[p-Ser204]-Antibody-Western-Blot-NBP2-29665-img0001.jpg "Western Blot: PAK1 [p Ser204] Antibody [NBP2-29665]")
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Applications: | WB |
![Western Blot: PAK1 Overexpression Lysate [NBP2-09482]](https://resources.bio-techne.com/images/products/PAK1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-09482-img0001.jpg "Western Blot: PAK1 Overexpression Lysate [NBP2-09482]")
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
Highly potent PAK1 and PAK2 inhibitor
| Chemical Name: | 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile |
| Purity: | ≥98% (HPLC) |
